Yes
Speaker Series: Crystal Pressure in Nanoscale Pores by Jim Wilking, PhD

This event occurred in the past

Speaker Series: Crystal Pressure in Nanoscale Pores by Jim Wilking, PhD

This event occurred in the past

Speaker Series: Crystal Pressure in Nanoscale Pores by Jim Wilking, PhD

This event occurred in the past

Date and Time

  • Thursday, November 8, 2018 at 12:15 p.m.

Location

Shiley Center for Science and Technology, 232

5998 Alcala Park San Diego, CA 92110

Cost

0

Details

Please join us Thursday, Nov. 8 for a conversation with Dr. Wilking on his research across soft matter physics over lunch. Read on for more information on the part of his research that he will be focusing on in his talk!

Most pharmaceutical compounds must be delivered to the bloodstream to take effect in the body. For orally-administered drugs, slow dissolution in the gastrointestinal fluid is often the rate-limiting step in the pathway to the bloodstream. This severely limits drug bioavailability, reduces the effectiveness of these compounds, and precludes the development of new compounds. Here, we introduce a simple approach for increasing the bioavailability of poorly water-soluble organic actives. By structuring compounds within the interconnected, nanoscale pore space of a colloidal packing we engineer composites that rapidly disintegrate in water, exposing the nanostructured organic active and leading to enhanced dissolution rates and bioavailability. Composite breakup is driven by the growth of nanoscale crystals, which Ostwald ripen and exert sufficient pressure on the walls of the confining pores to overcome the tensile yield stress of the composite. Beyond pharmaceutical formulations, these results are relevant for understanding physical processes such as salt damage to buildings and road damage due to frost heave.

Dr. James (Jim) Wilking is an assistant professor in the Department of Chemical and Biological Engineering at Montana State University in Bozeman. His laboratory is located in the Center for Biofilm Engineering. He is interested in research problems involving the physics of soft or biological materials. Dr. Wilking earned his PhD in Chemistry from UCLA and spent five years as a postdoctoral fellow in the School of Engineering and Applied Sciences at Harvard University before moving to MSU in 2014.

This event is open to the public

Post Contact

Crystal Ibarra
crystalibarra@sandiego.edu
(619) 260-4058

Contact Information

Community and Government Relations
Degheri Alumni Center Room 214
5998 Alcalá Park
San Diego, CA 92110

Phone: (619) 260-4297
Fax: (619) 260-6820
mpfister@sandiego.edu

Click to see map to Degheri Alumni Center Room 214
Building Location on Campus Map

View Map and Building Location