C H E M P L O Y M E N T A B S T R A C T S - APRIL 2007
CHEMPLOYMENT 605
The
Research Chemistry Department at Amylin Pharmaceuticals is currently in a high
growth phase and has 6 new positions at the following levels. Please copy and
paste the individual link into your web browser to read the full job
description and directly apply on line.
Position Titles
Sr.
Scientific Investigator (AMLN-02765)
http://careers.amylin.com/jobDetail.asp?id=12415&p=1
Sr.
Staff Scientist (AMLN-02766)
http://careers.amylin.com/jobDetail.asp?id=12416&p=1
Staff
Scientist (AMLN-02767)
http://careers.amylin.com/jobDetail.asp?id=12417&p=1
Research
Associate II/Sr. Research Associate
(AMLN-02768) (3 Openings)
http://careers.amylin.com/jobDetail.asp?id=12418&p=1
Description of Company
Amylin
Pharmaceuticals is committed to improving lives through the discovery,
development and commercialization of innovative medicines.
Amylin
offers competitive compensation, benefits and stock options. Amylin maintains a drug- and
alcohol-free workplace and all offers of
employment are contingent upon satisfactory completion of a pre-employment drug and alcohol test.
Application Instructions
Please
apply online at careers.amylin.com, and select "Research Chemistry"
as the department.
AA/EEO Employer.
CHEMPLOYMENT 606
Position Title
Scientist, Medicinal Chemistry
Job Description
The
successful candidate will be responsible for lead optimization in the
identification of new therapeutic agents.
Key
Responsibilities
- Plan and execute the synthesis of organic molecules for
evaluation in drug discovery projects.
- Conduct research towards solving problems in the synthesis
of target organic molecules.
- Evaluate the SAR from multiple biological experiments and
propose new compounds for chemical
synthesis.
- Participate on drug discovery project teams.
- Prepare and communicate in both oral and written form,
reports of research results.
- Will analyze reports from experiments and propose solutions
to problems.
QUALIFICATIONS DESIRED
- Requires a Ph.D. in Organic Chemistry
with at least 5 years of post-doctoral and industry experience.
- Requires successful track record in
small molecule drug discovery, and strong background in modern
synthetic chemistry,
chromatographic, and analytical techniques including HPLC, NMR and MS.
Description of Company
Phenomix Corporation invents and develops novel drugs to
inhibit therapeutic targets in the protease and kinase families. Phenomix has a
portfolio of programs underway in multiple indications. The most advanced
programs are a Phase 2 inhibitor of the protease DPP4 for treatment of Type 2
diabetes and a preclinical program inhibiting NS3 protease for treatment of
hepatitis C. Further information on
our programs may be found on our website at www.phenomix.com.
Application Instructions
Please forward your resume to jobs@phenomix.com.
CHEMPLOYMENT 607
Position Title
Process Chemist/CMC Manager
Job Description
The
Process Chemist/CMC Manager/Senior Manager, will provide
leadership in process chemistry for PhenomixÕ preclinical and phase 1-3
development projects.
Key
Responsibilities
- Develop strategy for process
development and API manufacturing for preclinical, nonclinical and clinical
studies and product registration.
- Design and troubleshoot synthetic
routes and scale up plans for API manufacturing.
- Ensure the API demands of companyÕs
projects are met.
- Evaluate, select, and manage process
CROs.
- Write process reports and regulatory
documents.
- Source
raw materials
QUALIFICATIONS DESIRED
- BS/MS with 8-10 years/Ph.D. with 3-5
years experience in process chemistry
in pharmaceutical or
biotech industry;
- Hands on experience and track record in
pharmaceutical process development, particularly with late
development projects;
- Familiarity with CMC activities and
regulatory requirements;
- Proven project management skills;
- Excellent oral and written
communication skills.
Description of Company
Phenomix Corporation
invents and develops novel drugs to inhibit therapeutic targets in the protease
and kinase families. Phenomix has a portfolio of programs underway in multiple
indications. The most advanced programs are a Phase 2 inhibitor of the protease
DPP4 for treatment of Type 2 diabetes and a preclinical program inhibiting NS3
protease for treatment of hepatitis C.
Further information on our programs may be found on our website at
www.phenomix.com.
Application Instructions
Please forward your resume to jobs@phenomix.com.
CHEMPLOYMENT 608
Position Title
ADME Chemistry Position
Job Description
Positions
Role:
* Recuitment and leadership of ADME
Scientists
* Ability to work with a Medicinal
Chemistry group on joint lead optimization projects
* Provide consultancy on ADME
optimization issues
* Work with BD to generate business
* Work with ADME group in UK to ensure
alignment of science and business
Requirements:
* Expertise in pharmacokinetic anaylsis
and interpretation
* Min 5+ years experience in early ADME
and development of running in vitro ADME
assays
* Experience interacting with and
supporting drug discovery projects
* Good interpersonal, communication and
management skills
* Comfortable giving scientific
presentations
* Ability to travel
QUALIFICATIONS DESIRED
* 10+ years ADME industry experience
* Experience with in silico ADME methods
and with physiochemical measurements for
evaluating potential drugs
Description of Company
For
further information on job and company please visit our website at www.biofocusdpi.com
Application Instructions
email
resume to: jobs_us@glpg.com
CHEMPLOYMENT 609
Position Title
Research Scientist, Medicinal
Chemistry, San Diego, CA
Job Description
Medicinal chemistry. Carry out the design and synthesis of
new chemical entities suitable for driving a drug discovery program from the
drawing board to the clinic.
QUALIFICATIONS DESIRED
A Ph.D. (0-5 years) or M.S. (3-10 years) in synthetic
organic chemistry with demonstrated success in modern approaches to multi-step
organic synthesis is required. The successful candidates must thrive in a team
oriented environment and be able to work efficiently in an early stage
discovery company. Structure based drug design experience is a plus.
Description of Company
Trius Therapeutics is discovering and developing
innovative antibacterial drugs for the treatment of life-threatening
infections. The companyÕs lead product candidate, TR-701 is a novel oral and IV
oxazolidinone antibiotic with potent activity against Gram positive bacterial pathogens.
TriusÕ pipeline includes three additional structure-based drug design programs
directed against novel antibacterial targets. For more information, visit www.triusrx.com.
Application Instructions
Interested candidates please e-mail resumes to
careers@triusrx.com.
CHEMPLOYMENT 610
Position Title
Senior Chemist
Job Description
Candidates will work within the oligonucleotide production
team at the US facility of Eurogentec, an International biotechnology company.
QUALIFICATIONS DESIRED
Candidates must have a chemistry background, excellent
communication skills and the ability to work well within a team environment.
The ability to work to ISO9000 accreditation standards is essential. Experience
with oligonucleotide synthesis, purification and QC is desirable but full
training will be provided.
Description of Company
Eurogentec is a global supplier of molecular biology
reagents.
www.eurogentec.com
Application Instructions
For more information or to apply for this post, please
contact Dr Catherine McKeen at c.mckeen@eurogentec.com.
CHEMPLOYMENT 611
Position Title
Sr.
Scientist - Medicinal Chemistry
Job Description
- Design,
develop synthetic routes, and synthesize compounds directed towards drug
candidates.
- Design
synthetic targets and viable synthetic routes, and synthesize target molecules
- Develop
structure-activity relationships using biological as well as DMPK data
- Conduct and
interpret spectral and other analytical data independently
- Present
data and compose scientific papers for publication
- Demonstrate creativity, inventiveness and innovation to
advance drug discovery independently
QUALIFICATIONS DESIRED
- Ph.D. (1-4 yrs. exper.), M.S. (5-7 yrs. exper.), or B.S.
(8+ yrs. exper.) in Organic or Medicinal
Chemistry.
- Practical experience in scientific discipline.
- Clear understanding of experimental design.
Description of Company
Located
in Costa Mesa, Ardea Biosciences is focused on the discovery, development and
commercialization of novel treatments for HIV, cancer and inflammatory
diseases.
Application Instructions
Please send us your resume at: careers@ardeabio.com.
Visit us at www.ardeabiosciences.com.
CHEMPLOYMENT 612
Position Title
Sr.
Scientist - Process Chemistry
Job Description
- Design and develop synthetic routes geared to optimizing the chemical synthesis of
drug
candidates.
- Design synthetic targets and viable synthetic routes,
and synthesize target molecules
optimizing
the scale-up process, while maintaining efficacy
- Assess, analyze, and provide solutions to the viability
of synthetic sequences as practical
routes for
drug candidates
- Conduct and interpret spectral and other analytical data
independently
- Conduct organic compound separation techniques
- Demonstrate principles of working under cGMP
- Present data and compose scientific papers for
publication
QUALIFICATIONS DESIRED
- Ph.D. (1-4 yrs. exper.), M.S. (5-7 yrs. exper.) or B.S.
(8+ yrs. exper.) in Organic or
Medicinal Chemistry
- Practical
experience in scientific discipline.
- Clear understanding
of experimental design.
Description of Company
Located
in Costa Mesa, Ardea Biosciences is focused on the discovery, development and
commercialization of novel treatments for HIV, cancer and inflammatory
diseases.
Application
Instructions
Please send us your resume at: careers@ardeabio.com.
Visit us at www.ardeabiosciences.com.
CHEMPLOYMENT 613
Position Title
Research Scientist (Temporary)
Job Description
We seek
a temporary synthetic chemist to support our top priority drug discovery
projects. Primary responsibilities
will include:
*Independent
synthesis, purification and characterization of both parallel synthesis
libraries of compounds
as well as multi-step serial synthesis
compound projects.
*Detailed
routine documentation and periodic formal presentation of all work.
Regular performance of literature and
compound database searches to support projects
QUALIFICATIONS DESIRED
Education
*Bachelor's
degree in Synthetic Chemistry with 8+ years experience or Master's degree with
5+ years
relevant industrial experience or PhD
with 2-5 years relevant industrial or academic research experience
in synthetic chemistry
Required
Experience and Skills:
*Proven
ability to independently set up, execute and monitor a variety of synthetic
reactions in both a serial and parallel format
*Experience
in all types of purification and characterization techniques
*Excellent
understanding of all aspects of modern multi-step synthetic chemistry methods
and analytical techniques
*Experience
with automated LC/MS or preparative HPLC instrumentation is highly desirable
Description of Company
Vertex
Pharmaceuticals Incorporated is a
global biotechnology company committed to the discovery and development of
break-through small molecule drugs for serious diseases. The CompanyÕs strategy
is to commercialize its products both independently and in collaboration with
major pharmaceutical companies. VertexÕs product pipeline is focused on viral
diseases, inflammation, autoimmune diseases, cancer, pain and bacterial
infection. Vertex co-discovered the HIV protease inhibitor, Lexiva, with
GlaxoSmithKline.
Application Instructions
You may
apply for this position in one of the following ways: Submit your resume directly via the web at www.vrtx.com
Email
resume to hr@sd.vrtx.com
Fax:
858-404-6720
If you fax your resume, please specify the position in
which you are interested. E
O E
CHEMPLOYMENT 614
Position Title
Research Associate II/III
Job Description
Under direct supervision, RA is
expected to execute experiments, interpret results, and is individually
responsible for the accuracy or scientific research, documentation of results,
and the evaluation/analysis of data.
Essential duties include:
- Synthesis of compounds and
intermediaries for internal and external screening using both
conventional and microwave assisted chemistry
- Parallel and high throughput
synthesis for lead discovery and optimization
- Analysis of reaction products
using modern spectroscopic methods
- Documentation of experiments in
Electronic Lab Journal format
QUALIFICATIONS DESIRED
Education
BS/MS or equivalent, with 2-5 years of experience.
Experience
Organic Synthesis, experience with heterocyclic chemistry
preferred. Computing and technical
abilities with respect to instrumentation are essential.
Description of Company
Arena is a clinical-stage biopharmaceutical company
focused on discovering, developing and commercializing innovative oral drugs
for patients with serious diseases and disorders, such as obesity and insomnia. We have a diverse portfolio of drug
candidates,
both proprietary and partnered. Our lead proprietary drug candidate, lorcaserin
hydrochloride,
is intended for the treatment of obesity and is being evaluated in a Phase 3
clinical program.
Application Instructions
Email resume to jobs@arenapharm.com
RE: Job#01250307