Bishop Leo T. Maher Hall
- Freshman residence hall
- Houses classrooms and offices
- Theology and Religious Studies Department
- Media Center
- Aromas Coffee Shop
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Camino Hall
- Male Freshman residence hall
- Houses classrooms and offices
- Departments of Communication Studies, Art, Art History, Architecture, Music and Theatre Arts
- Shiley Theatre
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Copley Library
- Facility for undergraduate and graduate students
- Study rooms
- Computer access
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Degheri Alumni Center
- Home for all USD Alumni
- Parent Relations
- Alumni Relations
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Donald P. Shiley Center for Science and Technology
- Departments of Biology, Chemistry, Marine Science, Physics, Biochemistry and Environmental Studies
- Over 70 laboratories
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Founders Hall
- Female freshman residence hall
- Houses classrooms and offices
- College of Arts and Sciences and Office of the Registrar
- Departments of English, Languages and Literatures, Philosophy
- Founders Chapel
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Hahn Pavilion
- School of Nursing
- Houses classrooms, offices, seminar rooms and faculty and student lounges
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Hahn University Center
- Dining Facilities and student services such as the ITS Help Desk and One Stop Services
- Houses meeting rooms, lounges, office space, activity areas, and general purpose rooms
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Hughes Administration Center
- Departments of Financial Aid, Provost office, Payroll, and many other important USD departments
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The Immaculata Church
- A separate parish from USD serving both the San Diego community and the USD community
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The Institute for Peace & Justice
- School of Peace Studies
- Houses an auditorium, multi-purpose rooms, classrooms, and offices
- Departments of History and Political Science
- La Paloma
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Loma Hall
- USD Torero Store and Mail Services
- Departments of Engineering, Physics, and Sociology
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Manchester Conference Center
- Provides conference rooms and meeting rooms, offices, and an auditorium
- Continuing Education Program
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Mother Rosalie Hill Hall
- School of Leadership & Education Sciences
- Houses classrooms, offices, and conference rooms
- Bert's Bistro
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Olin Hall
- School of Business Administration
- Houses offices, classrooms, lounges for faculty and staff, and a computer lab
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Pardee Legal Research Center
- Library for undergraduate students, graduate students, and especially law students
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Sacred Heart Hall
- Joins Camino Hall and Founders Hall
- Houses ROTC and a performing arts practice theater
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Serra Hall
- Departments of Computer Science, Mathematics, Psychology, and others
- Houses many student services such as the counseling center and the math center
- Provides classrooms, offices, and computer labs
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Warren Hall
- School of Law
- Houses classrooms, offices, and a courtoom which replicates that of the Supreme Court
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